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| |
Empagliflozin
|
Sitagliptin
|
p value
|
|---|
|
LVEF (%)
|
|
Baseline
|
73.4 ± 5.6
|
74.2 ± 4.5
|
0.620
|
|
12 weeks
|
73.5 ± 4.2
|
72.6 ± 5.0
|
0.539
|
|
Change
|
0.1 ± 4.0
|
−1.6 ± 3.0
|
0.138
|
|
Intragroup p value
|
0.932
|
0.026*
| |
|
%FS (%)
|
|
Baseline
|
42.9 ± 4.6
|
43.5 ± 4.0
|
0.625
|
|
12 weeks
|
42.9 ± 3.5
|
42.1 ± 4.1
|
0.521
|
|
Change
|
0.0 ± 3.5
|
−1.4 ± 2.7
|
0.147
|
|
Intragroup p value
|
0.985
|
0.024*
| |
|
E/e′
|
|
Baseline
|
10.9 ± 3.6
|
10.0 ± 2.7
|
0.397
|
|
12 weeks
|
10.3 ± 3.2
|
9.3 ± 1.8
|
0.188
|
|
Change
|
−0.5 ± 2.4
|
−0.8 ± 3.1
|
0.780
|
|
Intragroup p value
|
0.310
|
0.256
| |
|
E/A
|
|
Baseline
|
0.88 ± 0.25
|
1.01 ± 0.31
|
0.132
|
|
12 weeks
|
0.92 ± 0.23
|
1.01 ± 0.36
|
0.307
|
|
Change
|
0.04 ± 0.17
|
0.00 ± 0.19
|
0.500
|
|
Intragroup p value
|
0.296
|
0.963
| |
|
Cardiac index (L/min/m2)
|
|
Baseline
|
3.32 ± 0.75
|
3.14 ± 0.60
|
0.408
|
|
12 weeks
|
3.41 ± 0.60
|
3.03 ± 0.55
|
0.036*
|
|
Change
|
0.09 ± 0.74
|
−0.12 ± 0.53
|
0.296
|
|
Intragroup p value
|
0.566
|
0.325
| |
|
LV mass (g)
|
|
Baseline
|
153.6 ± 43.0
|
161.1 ± 38.2
|
0.555
|
|
12 weeks
|
152.1 ± 44.4
|
155.1 ± 32.5
|
0.804
|
|
Change
|
−1.5 ± 15.9
|
−6.0 ± 19.7
|
0.424
|
|
Intragroup p value
|
0.666
|
0.180
| |
- Data are presented as the mean ± SD (n = 21 for both groups). p values < 0.05 indicate significant differences. Comparisons were performed by one-sample t-test in each group, and two-sample t-tests between groups. LVEF: left ventricle ejection fraction, FS: fractional shortening, E/e′: ratio of mitral peak velocity of early filling to early diastolic mitral annular velocity, E/A: early filling/atrial filling ratio. *p < 0.05
