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Table 4 Association of NAFLD with MACE risk in multivariable Cox regression

From: Metabolic syndrome, fatty liver, and artificial intelligence-based epicardial adipose tissue measures predict long-term risk of cardiac events: a prospective study

  HR 95% CI P value
Model 1: adjusted for CAC score + EAT volume
 NAFLD 1.78 1.21–2.61 0.003
 EAT volume, cm3a 1.48 1.18–1.86 0.001
 CAC scorea 1.28 1.23–1.33 < 0.001
Model 2: adjusted for CAC score + EAT attenuation
 NAFLD 1.80 1.23–2.65 0.003
 EAT attenuation, HU 0.96 0.93–0.98 0.002
 CAC score 1.28 1.23–1.34 < 0.001
  1. Final models based on backward stepwise selection of variables at a Wald p-value of 0.05
  2. Co-variates entered in both models: age, male sex, MetS/diabetes status (no Mets or diabetes; MetS without diabetes; diabetes), LDL cholesterol, current smoker, past smoker, statin use, antihypertensive treatment
  3. aHazard ratios are per 2-fold increase/doubling of EAT volume (cm3) and CAC score
  4. CAC, coronary artery calcium; CT, computed tomography; EAT, epicardial adipose tissue; HU, Hounsfield units; MACE, major adverse cardiovascular events; MetS, metabolic syndrome; NAFLD, non-alcoholic fatty liver disease
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Cardiovascular Diabetology

ISSN: 1475-2840