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Univariate analysis HR (95% CI)
p value
Multivariate analysis HR (95% CI)
p value
A. Multivariate Cox regression analysis for parameters associated with CRT responders
Age
0.102 [0.11–0.968]
0.048
0.713 [0.007–1.773]
0.276
Automatic
0.795 [0.567–1.115]
0.184
3.636 [1.271–10.399]
0.016*
Beta blockers
1.176 [0.806–1.716]
0.401
1.156 [0.745–1.793]
0.517
BNP
1.001 [0.989–1.101]
0.868
1.001 [0.889–1.007]
0.816
COPD
1.446 [0.948–2.204]
0.087
1.527 [0.935–2.495]
0.091
CRP
1.101 [0.992–1.280]
0.274
1.017 [0.995–1.041]
0.136
HbA1c
1.118 [0.851–1.315]
0.643
1.181 [0.922–1.472]
0.123
Hypertension
0.898 [0.619–1.302]
0.569
0.895 [0.561–1.430]
0.644
LVEF
1.006 [0.970–1.044]
0.736
1.036 [0.993–1.081]
0.102
NYHA 3
1.176 [0.840–1.647]
0.345
1.829 [0.923–3.626]
0.084
Obesity
1.497 [1.290–1.852]
0.011
1.330 [0.829–1.843]
0.082
QRS duration
0.989 [0.971–1.008]
0.255
0.991 [0.971–1.011]
0.379
SonR
10.2 [5.227–19.952]
0.002
2.863 [1.537–6.231]
0.006*
6MWT
1.001 [0.993–1.007]
0.926
1.010 [0.993–1.007]
0.994
B. Multivariate Cox regression analysis for parameters associated with hospitalizations for heart failure
Age
1.012 [0.873–1.322]
0.958
0.997 [0.671–1.201]
0.240
Automatic
0.795 [0.567–1.115]
0.184
1.166 [0.118–1.504]
0.895
Beta blockers
1.301 [0.587–2.885]
0.517
0.844 [0.336–2.122]
0.718
BNP
1.002 [1.001–1.301]
0.011
1.002 [1.001–1.040]
0.125
COPD
0.561 [0.276–1.141]
0.111
2.364 [0.907–6.158]
0.078
CRP
1.011 [0.978–1.046]
0.507
1.032 [0.982–1.084]
0.219
HbA1c
1.142 [0.816–1.913]
0.143
0.915 [0.589–1.541]
0.762
Hypertension
1.991 [1.003–3.952]
0.049
2.503 [0.809–7.745]
0.111
LVEF
1.029 [0.956–1.108]
0.443
1.061 [0.960–1.172]
0.245
NYHA 3
0.531 [0.258–1.096]
0.087
0.962 [0.289–3.202]
0.950
Obesity
0.905 [0.276–2.965]
0.869
1.093 [0.220–5.429]
0.913
QRS duration
0.964 [0.927–1.020]
0.066
0.960 [0.919–1.003]
0.069
SonR
0.074 [0.004–1.292]
0.074
0.679 [0.118–1.154]
0.932
6MWT
0.999 [0.985–1.013]
0.891
0.995 [0.980–1.011]
0.552
C. Multivariate Cox regression analysis for parameters associated with cardiac deaths
Age
0.953 [0.795–1.541]
0.543
1.362 [0.632–1.872]
0.361
Automatic
1.670 [0.489–5.705]
0.413
0.111 [0.001–2.583]
0.427
Beta blockers
2.099 [0.525–3.024]
0.176
1.095 [0.048–1.435]
0.945
BNP
1.001 [0.998–1.004]
0.681
0.999 [0.996–1.003]
0.679
COPD
1.119 [0.031–1.447]
0.072
2.138 [0.942–4.002]
0.401
CRP
0.913 [0.807–1.034]
0.151
0.903 [0.734–1.112]
0.338
HbA1c
1.601 [0.925–2.563]
0.142
3.224 [0.841–4.389]
0.106
Hypertension
0.226 [0.029–1.764]
0.156
0.515 [0.026–1.019]
0.663
LVEF
1.127 [0.964–1.316]
0.133
1.126 [0.855–1.482]
0.397
NYHA 3
0.615 [0.180–2.102]
0.439
0.458 [0.008–2.618]
0.705
Obesity
2.283 [0.002–3.248]
0.521
0.759 [0.001–1.621]
0.993
QRS duration
0.951 [0.885–1.021]
0.164
0.897 [0.782–1.016]
0.087
SonR
0.056 [0.001–8.699]
0.263
0.010 [0.001–5.267]
0.520
6MWT
0.992 [0.968–1.016]
0.509
0.973 [0.919–1.031]
0.355
D. Multivariate Cox regression analysis for parameters associated with all cause deaths
Age
1.782 [1.053–2.302]
0.001
1.362 [0.809–1.780]
0.563
Automatic
1.471 [0.570–3.795]
0.425
1.744 [0.270–2.713]
0.179
Beta blockers
2.009 [0.582–6.490]
0.270
3.338 [0.684–6.781]
0.096
BNP
0.999 [0.996–1.002]
0.434
0.998 [0.994–1.021]
0.258
COPD
0.268 [0.106–0.680]
0.006
2.802 [0.493–5.192]
0.245
CRP
0.918 [0.837–1.007]
0.070
0.915 [0.792–1.057]
0.915
HbA1c
0.832 [0.503–1.742]
0.430
0.587 [0.201–3.105]
0.224
Hypertension
0.027 [0.001–1.801]
0.092
0.898 [0.648–1.547]
0.936
LVEF
1.008 [0.916–1.110]
0.869
0.879 [0.001–5.644]
0.713
NYHA 3
0.292 [0.096–0.888]
0.030
1.966 [0.030–3.082]
0.465
Obesity
2.289 [0.014–3.766]
0.407
0.468 [0.009–1.821]
0.099
QRS duration
0.958 [0.907–1.012]
0.128
0.958 [0.885–1.037]
0.284
SonR
0.191 [0.005–7.540]
0.378
1.684 [0.101–5.647]
0.713
6MWT
1.009 [0.991–1.028]
0.339
1.004 [0.977–1.031]
0.791
Italic values indicate a significant p value (p < 0.05)
* Is for statistical significant (p < 0.05). BNP, B type natriuretic peptide; COPD, chronic obstructive pulmonary disease; CRP, C reactive protein; HbA1c, glycated hemoglobin 1Ac type; LVEF, left ventricle ejection fraction; NYHA 3, New York Heart Association 3 class; SonR, values of SonR signals; 6MWT, 6 min walking test. Multivariate Cox regression analysis for parameters associated with CRT responders
