Long-term outcomes of medical therapy versus successful recanalisation for coronary chronic total occlusions in patients with and without type 2 diabetes mellitus

Table 3 Clinical outcomes of all patients with and without diabetes, and of all patients with and without diabetes stratified according to medical therapy or successful CTO-PCI

Total population	Non-diabetes	Diabetes	P value
Total population	(n = 1260)	(n = 755)	P value
Cardiac death	59 (4.7)	38 (5.0)
Adjusted HR (95% CI)	1	1.13 (0.73–1.75)	0.597
MI	86 (6.8)	69 (9.1)
Adjusted HR (95% CI)	1	1.38 (0.98–1.92)	0.058
TVR	155 (12.3)	113 (15.0)
Adjusted HR (95% CI)	1	1.41 (1.10–1.81)	0.006
MACE	257 (20.4)	192 (25.4)
Adjusted HR (95% CI)	1	1.32 (1.09–1.61)	0.005

Patients with diabetes	Medical therapy	Successful PCI	P value
Patients with diabetes	(n = 506)	(n = 249)	P value
Cardiac death	33 (6.5)	5 (2.0)
Adjusted HR (95% CI)	1	0.29 (0.10–0.80)	0.017
MI	50 (9.9)	19 (7.6)
Adjusted HR (95% CI)	1	0.75 (0.44–1.30)	0.305
TVR	79 (15.6)	34 (13.7)
Adjusted HR (95% CI)	1	0.76 (0.50–1.17)	0.212
MACE	146 (28.9)	46 (18.5)
Adjusted HR (95% CI)	1	0.61 (0.42–0.87)	0.006

Patients with diabetes	Medical therapy	Successful PCI	P value
Patients with diabetes	(n = 791)	(n = 469)	P value
Cardiac death	41 (5.2)	18 (3.8)
Adjusted HR (95% CI)	1	0.94 (0.51–1.70)	0.825
MI	56 (7.1)	30 (6.4)
Adjusted HR (95% CI)	1	1.01 (0.62–1.65)	0.959
TVR	109 (13.8)	46 (9.8)
Adjusted HR (95% CI)	1	0.85 (0.59–1.22)	0.389
MACE	180 (22.8)	77 (16.4)
Adjusted HR (95% CI)	1	0.85 (0.64–1.15)	0.294

Values are presented as n (%)
CI confidence interval(s), HR hazard ratio, MACE major adverse cardiovascular events, MI myocardial infarction, PCI percutaneous coronary intervention, TVR target-vessel revascularization

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