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Anagliptin (n = 148)
|
P
|
Sitagliptin (n = 159)
|
P
|
Pa
|
|---|
|
Baseline
|
52 weeks
|
Baseline
|
52 weeks
|
|---|
|
Body mass index
|
26.7 ± 3.9
|
26.5 ± 4.1
|
0.04
|
25.8 ± 3.6
|
25.8 ± 3.8
|
0.92
|
0.12
|
|
Waist circumference (cm)
|
94.2 ± 11.1
|
93.6 ± 10.9
|
0.30
|
92.7 ± 9.8
|
92.4 ± 9.6
|
0.56
|
0.69
|
|
AST (IU/L)
|
23 (18–30)
|
23 (18–29)
|
0.14
|
20 (18–25)
|
21 (18–27)
|
0.02
|
< 0.01
|
|
ALT (IU/L)
|
23 (17–34)
|
22 (14–33)
|
0.12
|
18 (15–26)
|
19 (14–26)
|
0.42
|
0.08
|
|
γGTP (IU/L)
|
30 (18–46)
|
27 (19–42)
|
0.16
|
24 (18–35)
|
24 (18–36)
|
0.12
|
0.07
|
|
Blood urea nitrogen (mg/dL)
|
16.7 ± 6.0
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16.8 ± 5.3
|
0.89
|
17.1 ± 5.6
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17.5 ± 5.5
|
0.30
|
0.51
|
|
Creatinine (mg/dL)
|
0.84 ± 0.27
|
0.86 ± 0.29
|
0.04
|
0.86 ± 0.29
|
0.87 ± 0.29
|
0.17
|
0.34
|
|
eGFR (mL/min/1.73 m2)
|
68.9 ± 20.7
|
66.8 ± 20.6
|
0.02
|
66.9 ± 18.5
|
65.7 ± 18.4
|
0.06
|
0.44
|
|
Total cholesterol (mg/dL)
|
190 ± 30
|
186 ± 28
|
0.02
|
186 ± 29
|
191 ± 27
|
0.01
|
< 0.01
|
|
LDL cholesterol (mg/dL)
|
112 ± 22
|
108 ± 22
|
0.01
|
110 ± 22
|
112 ± 21
|
0.15
|
< 0.01
|
|
HDL cholesterol (mg/dL)
|
54 ± 14
|
53 ± 13
|
0.43
|
55 ± 13
|
56 ± 13
|
< 0.01
|
0.01
|
|
Triglycerides (mg/dL)
|
136 (98–190)
|
134 (97–185)
|
0.80
|
114 (80–158)
|
110 (82–160)
|
0.22
|
0.55
|
|
Fasting glucose (mg/dL)
|
143 ± 42
|
147 ± 48
|
0.18
|
140 ± 39
|
146 ± 44
|
< 0.01
|
0.47
|
|
Insulin (µU/mL)
|
8.0 (5.7–12.0)
|
8.5 (5.3–13.3)
|
0.51
|
6.9 (4.5–11.0)
|
7.1 (4.7–11.5)
|
0.54
|
0.39
|
|
HbA1c (%)
|
7.1 ± 0.8
|
7.1 ± 0.9
|
0.71
|
6.9 ± 0.7
|
7.0 ± 0.9
|
0.04
|
0.28
|
- Variables are expressed as mean ± SD or medians (interquartile ranges)
- AST aspartate transaminase, ALT alanine transaminase, eGFR estimated glomerular filtration rate, γGTP γ-glutamyl transpeptidase
- aFor group difference in absolute change from baseline to 52 weeks
